Effects of Hypericum perforatum extract on IgG titer, leukocytes subset and spleen index in rats

نویسندگان

  • Abdol Mansur Tahmasbi Department of Animal Sciences, College of Agriculture, Ferdowsi University of ‎Mashhad, Mashhad, I. R. Iran
  • Ali Reza Haghparast Department of Pathology, College of Veterinary Medicine, Ferdowsi of University of ‎Mashhad, Mashhad, I. R. Iran
  • Javad Arshami Department of Animal Sciences, College of Agriculture, Ferdowsi University of ‎Mashhad, Mashhad, I. R. Iran
  • Tahereh Aghili Graduate Student in Animal Sciences, College of Agriculture, Ferdowsi University of ‎Mashhad, Mashhad, I. R. Iran
چکیده مقاله:

Objectives: Hypericum perforatum L. is a medicinal plant containing many polyphenolic compounds, ‎including flavonoids and phenolic acids with antidepressant and anti-inflammatory properties. ‎This study was investigated the effects of Hypericum perforatum extract (HPE) on immunity, ‎body weight (BW), and spleen index (SI) in rats.‎ Materials and Methods: A total of 24 Wistar male rats were randomly received 4 different doses (6 rats each) of HPE ‎‎(0, 100, 200 and 400 mg/kg BW) intraperitoneally for 14 days using a completely ‎randomized design. On days 1 and 7, rats were received 0.5 ml SRBC (10%) injection. Blood ‎samples were collected on day 14 to evaluate IgG titer and leukocyte count. On days 1, 7 and ‎‎14, the BW and on day 14 spleen were weighted for SI. ‎ Results: The IgG titer increased with higher doses of HPE. The HPE increased number of ‎lymphocytes at 200 mg but decreased at 400 mg, number of neutrophils decreased at 200 mg ‎but increased at 400 mg, and number of monocytes increased at 100 mg and 200 mg but ‎decreased at 400 mg (p

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effects of hypericum perforatum extract on igg titer, leukocytes subset and spleen index in rats

objectives: hypericum perforatum l. is a medicinal plant containing many polyphenolic compounds, ‎including flavonoids and phenolic acids with antidepressant and anti-inflammatory properties. ‎this study was investigated the effects of hypericum perforatum extract (hpe) on immunity, ‎body weight (bw), and spleen index (si) in rats.‎ materials and methods: a total of 24 wistar male rats were ran...

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عنوان ژورنال

دوره 4  شماره 6

صفحات  413- 419

تاریخ انتشار 2014-11-01

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